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MCP live MCP 2026-07-28 streamable-http

Folklore Clinical Variant Interpretation MCP

io.github.helena-bioinformatics/folklore

ACMG/AMP germline variant classification, gene profiles, disease associations and literature.

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Watch this dependency Share evidence report
Uptime
100.0%
7 direct probes · 30d
Response
324ms
last probe
Tools
11
callable
Resources
1
readable
Prompts
5
available
Primary URL
https://api.helena.bio/folklore/v1/mcp
Score: 100/100
Handshake verified by our own probe.
pass Answers the MCP handshake 50/50
The handshake and the list calls succeeded on the primary URL.
pass Lists tools, resources or prompts 30/30
11 tools, 1 resources, 5 prompts returned.
pass 3 or more catalogue items 10/10
17 items in total; 3 or more earns these points.
pass Describes itself 10/10
93 characters; more than 30 earns these points.

Tools · 11

classify_germline_variant

Classify one GRCh38 germline nuclear SNV or simple indel smaller than 50 bp under ACMG/AMP. Accepts genomic, coding or protein HGVS, coordinates, SPDI, rsID or a returned canonical key. Returns normal…

search_variant_literature

Resolve one GRCh38 germline variant and retrieve publications from the PubMed-derived genetics corpus. Exact variant mentions rank ahead of broader gene associations. Returns match types, source links…

get_publication_details

Retrieve one PMID from the PubMed-derived genetics corpus, including title, abstract, authors, journal, publication types, MeSH terms, gene and variant mentions, retraction status and PubMed/PMC links…

search_literature_corpus

Search the genetics Literature Corpus by question, PMID, DOI, PMCID, gene, variant, phenotype, HPO or OMIM concept. Known publication identifiers provide exact anchors. Returns ranked publications, ma…

support_helena

Retrieve Helena Good campaign, rules, manifest and MCP connection URLs.

get_gene_disease_associations

Find diseases associated with an exact gene symbol or HGNC identifier. Returns ClinGen gene-disease validity assertions, relation-specific inheritance, source reports and snapshot provenance, includin…

search_disease_genes

Find genes associated with an exact MONDO identifier or disease-name search. Returns ClinGen validity assertions with inheritance, source reports and snapshot provenance. Name searches can return mult…

resolve_gene

Resolve a human gene symbol, previous symbol, alias, HGNC, Ensembl or NCBI Gene identifier. Returns exact, alias, ambiguous, not_found or withdrawn status with candidates and identity_snapshot_id. Use…

get_gene_profile

Read the selected gene_id and immutable snapshot_id from resolve_gene. Returns overview, disease validity, dosage, mechanisms, transcripts, native assemblies, constraint, ClinVar summaries and consequ…

get_gene_section

Read a gene-profile section using gene_id, snapshot_id and its returned opaque cursor. Returns source records, assembly/release, coverage, totals, count units and provenance. snapshot_unavailable requ…

search_gene_literature

Retrieve a live publication capture for a resolved gene_id and snapshot_id. Returns source links, match labels, capture time/hash, degradation and gene/snapshot/sort-bound cursors. This capture is sep…

Resources · 1

folklore-variant-classification-view

Interactive, read-only rendering of Folklore variant classifications.

ui://folklore/variant-classification/v1.html

Prompts · 5

classify_germline_variant

Resolve one GRCh38 germline variant and report its automated ACMG/AMP classification, applied criteria, annotations and source provenance.

assess_vus

Assess the classification and applied criteria for a variant of uncertain significance.

explain_acmg_classification

Explain the returned ACMG/AMP criteria and source annotations for one supported variant.

verify_variant_identity

Resolve one public variant expression to its normalized identity and stop for user disambiguation rather than selecting an allele.

compare_variant_literature

Resolve a variant and compare its classification and annotations with associated publications.

How to use

Claude Desktop or claude.ai: add a custom connector (Customize → Connectors; on Team and Enterprise plans an owner adds it under Organization settings → Connectors) with this server URL: https://api.helena.bio/folklore/v1/mcp

Cursor or Cline: add to your MCP config:

{
  "mcpServers": {
    "folklore_clinical_variant_interpretation_mcp": {
      "url": "https://api.helena.bio/folklore/v1/mcp",
      "transport": "streamable-http"
    }
  }
}

Source: github.com/helena-bioinformatics/folklore-mcp