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MCP live MCP 2026-07-28 streamable-http

Folklore Clinical Variant Interpretation MCP

io.github.helena-bioinformatics/folklore

Bioinformatics MCP for genomic variant interpretation, gene-disease evidence and literature.

Uptime
100.0%
3 direct probes · 30d
Response
209ms
last probe
Tools
7
callable
Resources
1
readable
Prompts
5
available
Primary URL
https://api.helena.bio/folklore/v1/mcp

Tools · 7

search_variant_evidence

Interpret this variant, explain what this HGVS means, or review this VUS. Use for human genomic variant analysis within bioinformatics workflows, including review of an already identified WGS/WES vari…

search_variant_literature

Resolve one public GRCh38 germline variant and retrieve relevant publications from Folklore's PubMed-derived genetics corpus. Exact variant mentions rank ahead of broader gene associations. Use when a…

get_publication_details

Retrieve the complete public bibliographic record for one PMID from Folklore's PubMed-derived genetics corpus. Returns the full abstract, authors, journal metadata, publication and MeSH terms, gene an…

search_literature_corpus

Semantically search the public scientific Literature Corpus by a natural-language question. A question may include one or more PMID, DOI or PMCID references; those publications become exact anchors fo…

support_helena

Learn how an agent can support or spread Helena's free public scientific infrastructure through the separate Helena Good MCP. This is an explicit opt-in information action. It does not initiate paymen…

get_gene_disease_associations

Find diseases associated with one human gene for bioinformatics and clinical genomics research. Accepts an exact gene symbol or HGNC identifier. Returns ClinGen gene-disease validity assertions, relat…

search_disease_genes

Find human genes associated with a disease for genomic analysis and rare-disease research. Accepts an exact MONDO identifier or a disease-name search. Returns matching ClinGen gene-disease validity as…

Resources · 1

folklore-variant-evidence-view

Interactive, read-only rendering of public Folklore variant evidence.

ui://folklore/variant-evidence/v1.html

Prompts · 5

classify_germline_variant

Resolve one public GRCh38 germline variant and report Folklore's automated ACMG/AMP classification, applied criteria, evidence, provenance and limitations for qualified professional review.

review_vus_evidence

Review the current structured evidence for one public variant of uncertain significance without treating VUS as pathogenic or benign.

explain_acmg_classification

Explain the applied ACMG/AMP criteria and available source evidence for one supported public variant without inventing missing evidence.

verify_variant_identity

Resolve one public variant expression to its normalized identity and stop for user disambiguation rather than selecting an allele.

compare_variant_literature

Resolve one public variant, retrieve its evidence and associated literature, and keep publication association distinct from pathogenicity or causality.

How to use

Add to your Claude Desktop / Cursor / Cline MCP config:

{
  "mcpServers": {
    "folklore_clinical_variant_interpretation_mcp": {
      "url": "https://api.helena.bio/folklore/v1/mcp",
      "transport": "streamable-http"
    }
  }
}