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MCP live MCP 2025-11-25 streamable-http

world.sniff/sniff-mcp

world.sniff/sniff-mcp

Canine genomics for agents: breed allele frequencies, AI pathogenicity + OMIA clinical disease layer

Uptime
100.0%
1 direct probes · 30d
Response
3176ms
last probe
Tools
18
callable
Resources
0
readable
Prompts
0
available
Primary URL
https://mcp.sniff.world/mcp/

Tools · 18

ask

Ask Sniff a natural-language canine-genetics question and get a GROUNDED, CITED answer (or an honest abstain). Covers inherited diseases (OMIA) and their human homologs (the dog<->human disease bridge…

ask_the_graph

THE INSTRUMENT — ask a free-form CROSS-SPECIES genetics question and get FILTERED, HONEST HINTS (never a confident guess). It compiles your question into a typed query plan over the dog<->human edge-g…

disease_bridge

The fused OMIA disease layer as cited atoms. Give a `disease` (name or 'OMIA:001870-9615') for its genes, inheritance, human homolog (OMIM/Mondo bridge), and variant pathogenicity grade (AVCG, ACMG/AM…

ask_variant_context

THE headline query. Given a CanFam4 position (e.g. '5:56189113'), return the variant's global + popmax frequency, breed-stratified cross-breed frequencies, ESM2/Pangolin/phyloP pathogenicity, gene con…

variant_lookup

Single-variant lookup by CanFam4 position: ref/alt, global + popmax AF, consequence, gene, ESM2/Pangolin/phyloP, deleteriousness tier, canonical URL, provenance.

breed_variant_frequency

Breed-stratified allele frequency. Give a breed (e.g. 'bernese_mountain_dog') plus either a variant position or a gene symbol. Returns AF (+ rank) for the variant, or per-variant AFs in the gene.

gene_summary

Variants in a gene (by gene symbol), ranked by impact then ESM2 damage. Paginated (limit, default 25); returns total_variants. Use af_min to filter by global AF.

breed_summary

Breed profile: top damaging common variants (ESM2<=-5 & breed AF>=5%), n_dogs, breed group. Descriptive only — not a health ranking.

variant_search

Filtered discovery over all 9.67M variants. Predicates (combine freely): esm_max (ESM2 LLR <=), phylop_min (phyloP >=), popmax_min (popmax AF >=), gene_in (list of gene symbols), consequence, impact (…

nearest_breeds

Genetically nearest breeds to the given breed (top-10-PC Euclidean in canine genetic space). Answers 'what breeds are most genetically similar to X?' via the PCA-256 breed co-embedding.

breed_similarity

Genetic distance between two breeds (top-10-PC Euclidean). Lower = more genetically similar.

semantic_search

Faceted hybrid + semantic-ranker search over the whole knowledge base (diseases, breeds, Scout discoveries). Use for fuzzy/thematic intent ('drug sensitivity in herding dogs', 'breeds prone to eye dis…

disease_links

A canine inherited disease (name or OMIA id) -> its governed OMIA clinical record: mode of inheritance, causal gene(s), curated description (summary / clinical features / molecular genetics / patholog…

disease_lookup

Look up a canine inherited disease by name or OMIA id -> its governed OMIA clinical record (inheritance, causal gene(s), curated description, clinical signs, human OMIM analog + Mondo id, evidence bas…

search_diseases

Search the canine disease catalogue by free text -> ranked candidates [{omia_id, disease, url, score}]. Use before disease_lookup when the exact name is unknown. Dog-only.

breeds_in_atlas

List all 188 breeds with breed-stratified frequencies in the atlas.

genes_indexed

Top genes by number of variants in the atlas (discovery aid).

metadata

Atlas metadata: release, DOI, assembly, variant/breed counts, scope banner, and the RPC catalog.

How to use

Add to your Claude Desktop / Cursor / Cline MCP config:

{
  "mcpServers": {
    "world.sniff/sniff-mcp": {
      "url": "https://mcp.sniff.world/mcp/",
      "transport": "streamable-http"
    }
  }
}