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MCP live MCP 2026-07-28 http

pubchem-mcp-server

cyanheads/pubchem-mcp-server

Search PubChem compounds, properties, safety data, bioactivity, and cross-references.

Watch this dependency

Get before/after evidence when observed tools, schemas, authentication access, availability or the endpoint changes.

Inspect evidence and set up a watch Share public evidence report
Uptime
100.0%
5 direct probes · 30d
Response
1296ms
last probe
Tools
10
callable
Resources
0
readable
Prompts
0
available
Primary URL
https://pubchem.caseyjhand.com/mcp
Score: 100/100
Handshake verified by our own probe.
why this score
pass Answers the MCP handshake 50/50
The handshake and the list calls succeeded on the primary URL.
pass Lists tools, resources or prompts 30/30
10 tools, 0 resources, 0 prompts returned.
pass 3 or more catalogue items 10/10
10 items in total; 3 or more earns these points.
pass Describes itself 10/10
85 characters; more than 30 earns these points.

Tools · 10

pubchem_search_compounds

Search PubChem for chemical compounds by identifier (name, SMILES, or InChIKey, up to 25 per call), molecular formula in Hill notation, substructure or superstructure containment, 2D Tanimoto similari…

pubchem_get_compound_details

Get detailed compound information by CID. Returns physicochemical properties (molecular weight, SMILES, InChIKey, XLogP, TPSA, etc.), optionally with a textual description (pharmacology, mechanism, th…

pubchem_get_compound_image

Fetch a 2D structure diagram (PNG image) for a compound by CID.

pubchem_get_compound_3d_structure

Get a compound's default 3D conformer — atomic coordinates and bonds — for one CID. format="json" (default) returns atoms and bonds parsed into structured fields; format="sdf" returns the raw V2000 SD…

pubchem_get_compound_xrefs

Get external database cross-references for a compound: PubMed citations, patent IDs, gene/protein associations, registry numbers, and taxonomy IDs. Results are paged per type — capped at maxPerType wi…

pubchem_get_compound_safety

Get GHS (Globally Harmonized System) hazard classification and safety data for one or more compounds by CID. Returns signal word, pictograms, hazard statements (H-codes), and precautionary statements …

pubchem_get_bioactivity

Get a compound's bioactivity profile: which assays tested it, activity outcomes (Active/Inactive/Inconclusive), target identifiers (NCBI Gene ID, UniProt/GenBank accession), and quantitative values (I…

pubchem_get_compound_interactions

Get a compound's interaction data: drug-drug interactions (DrugBank), drug-food interactions, and chemical-target interactions (binding/activity from BindingDB, ChEMBL, and others). Each entry carries…

pubchem_search_assays

Find PubChem bioassays associated with a biological target. Search by gene symbol (e.g. "EGFR"), protein name, NCBI Gene ID, or UniProt accession. Returns a page of assay IDs (AIDs) — page past maxRes…

pubchem_get_summary

Get descriptive summaries for PubChem entities by ID. Supports assays (AID), genes (Gene ID), proteins (UniProt accession), and taxonomy (Tax ID). Up to 10 per call; identifiers past that are returned…

How to use

Add to your Claude Desktop / Cursor / Cline MCP config:

{
  "mcpServers": {
    "pubchem-mcp-server": {
      "url": "https://pubchem.caseyjhand.com/mcp",
      "transport": "http"
    }
  }
}